Suppressors of a UGG missense mutation in Escherichia coli

Pleiotropic Effects of Suppressors of a Lac-"operator Negative" Mutation in Escherichia Coli.

Suppression of a missense mutation in the L-ribulokinase gene of Escherichia coli.

HE L-arabinose gene-enzyme complex, except for the unlinked L-arabinose Tpermease gene, araE, is shown in Figure 1. araB and araA are the structural genes for the L-ribulokinase and L-arabinose isomerase, respectively; while araD is probably the structural gene for ~-ribulose-5-phosphate-4-epimerase ( ENGLESBERG 1961 ; ENGLESBERG et al. 1962; LEE and ENGLESBERG 1962,1963). The ma€ gene is a reg...

Adaptive mutation in Escherichia coli.

In 1988 John Cairns, Julie Overbaugh, and Stephan Miller published a paper entitled “The origin of mutants,” in which they suggested that bacteria could choose which mutations to make (11). Shortly thereafter, Cairns and I began collaborating on a National Science Foundation-funded project to investigate the genetic basis of what was popularly called “directed mutation” (although at the time we...

A Novel Missense Mutation in CLCN1 Gene in a Family with Autosomal Recessive Congenital Myotonia

Congenital recessive myotonia is a rare genetic disorder caused by mutations in CLCN1, which codes for the main skeletal muscle chloride channel ClC-1. More than 120 mutations have been found in this gene. The main feature of this disorder is muscle membrane hyperexcitability. Here, we report a 59-year male patient suffering from congenital myotonia. He had transient generalized myotonia, which...

Extragenic suppression of motA missense mutations of Escherichia coli.

The MotA and MotB proteins are thought to comprise elements of the stator component of the flagellar motor of Escherichia coli. In an effort to understand interactions among proteins within the motor, we attempted to identify extragenic suppressors of 31 dominant, plasmid-borne alleles of motA. Strains containing these mutations were either nonmotile or had severely impaired motility. Four of t...